| Abbeville | Lancaster | Building | 1978 |
| American/Consolidated Tobacco Companies | Lancaster | Building | 1990 |
| Andrews Bridge Historic District | Colerain Twnshp | District | 1988 |
| Ashley and Bailey Silk Mill | Marietta | Building | 1980 |
| B.F. Good & Company Leaf Tobacco Warehouse | Lancaster | Building | 1985 |
| Bachman and Forry Tobacco Warehouse | Columbia | Building | 1979 |
| Bangor Episcopal Church | Blue Ball | District | 1987 |
| Basch & Fisher Tobacco Warehouse | Lancaster | Building | 1990 |
| Baumgardner's Mill Covered Bridge | Willow Street | Structure | 1980 |
| Bausman Farmstead | Lancaster | Building | 1994 |
| Berger, John & Son, Company Tobacco Warehouse | East Hempfield Township | Building | 2014 |
| Big and Little Indian Rock Petroglyphs | Safe Harbor | Site | 1978 |
| Bird-in-Hand Hotel | Bird-in-Hand | Building | 1992 |
| Bitzer's Mill Covered Bridge | Ephrata | Structure | 1980 |
| Bowman, Jacob, Tobacco Warehouse | Lancaster | Building | 1990 |
| Bowmansville Roller Mill | Bowmansville | District | 1990 |
| Bridge in West Earl Township | Brownstown | Structure | 1988 |
| Brimmer, John, Tobacco Warehouse | Lancaster | Building | 1990 |
| Brown's, George, Sons Cotton and Woolen Mill | Mount Joy | Building | 1995 |
| Buchanan, James, House NHL | Lancaster | Building | 1966 |
| Bucher Thal Historic District | Denver | District | 1987 |
| Bucher, Joseph, House | Marietta | Building | 1979 |
| Buck Hill Farm Covered Bridge | Lititz | Structure | 1980 |
| Butcher's Mill Covered Bridge | Denver | Structure | 1980 |
| Byers-Muma House | East Donegal | Building | 2002 |
| Caernarvon Presbyterian Church | Churchtown | Building | 2015 |
| Cameron Estate | Mount Joy | Building | 1975 |
| Central Hotel | Mount Joy | Building | 1973 |
| Central Market | Lancaster | Building | 1972 |
| Chickies Historic District | Marietta Borough | District | 2005 |
| Colemanville Covered Bridge | Pequea | Structure | 1980 |
| Columbia Historic District | Columbia | District | 1983 |
| Columbia Wagon Works | Columbia Borough | Building | 2001 |
| Combination Baggage and Mail Car No. 5403 | Strasburg | Structure | 1979 |
| Conestoga Cork Works Building | Lancaster | Building | 1996 |
| Conestoga Town | Letort | Site | 1973 |
| Congregational Store | Lititz | Building | 1983 |
| Connell Mansion | Ephrata | Building | 1979 |
| Consolidation Freight Locomotive No. 1187 | Strasburg | Structure | 1979 |
| Consolidation Freight Locomotive No. 2846 | Strasburg | Structure | 1979 |
| Consolidation Freight Locomotive No. 7688 | Strasburg | Structure | 1979 |
| Cumberland Valley Car | Strasburg | Structure | 1979 |
| Davies, Edward, House | Churchtown | Building | 1991 |
| Davis, David, Farm | New Holland | District | 1994 |
| DDI Electric Locomotive No. 36 | Strasburg | Structure | 1979 |
| Dohner, Michael, Farmhouse | Lancaster | Building | 1980 |
| Donegal Mills Plantation | Mount Joy | Building | 1978 |
| Donegal Presbyterian Church Complex | East Donegal Township | District | 1985 |
| Douglass, John, House | Kirkwood | Building | 1990 |
| Duncan Island (36LA60,61) | Holtwood | Site | 1984 |
| Eby Shoe Corporation | Ephrata | Building | 1989 |
| Eisenlohr-Bayuk Tobacco Historic District | Lancaster | District | 1990 |
| Electric Locomotive No. 4859 | Strasburg | Site | 1982 |
| Ellicott, Andrew, House | Lancaster | Building | 1972 |
| Ephrata Cloister NHL | Ephrata | District | 1967 |
| Ephrata Commercial Historic District | Ephrata | District | 2006 |
| Erb's Covered Bridge | Rothsville | Structure | 1980 |
| Evans, Ann Cunningham, House | Caernarvon | Site | 2002 |
| Farmer's Southern Market | Lancaster | Building | 1986 |
| Flat Car No. 473567 | Strasburg | Structure | 1979 |
| Follmer, Clogg and Company Umbrella Factory | Lancaster | Building | 1986 |
| Forry's Mill Covered Bridge | Columbia | Structure | 1980 |
| Franklin and Marshall College Campus Historic District | Lancaster | District | 2003 |
| Freight Locomotive No. 5741 | Strasburg | Structure | 1979 |
| Frey-Haverstick Site (36LA6) | Washington Boro | Site | 1986 |
| Frey, Jacob L., Tobacco Warehouse | Lancaster | Building | 1990 |
| Friedman, Henry B., Tobacco Warehouse | Lancaster | Building | 1990 |
| Fulton Opera House NHL | Lancaster | Building | 1969 |
| Fulton, Robert, Birthplace NHL | Quarryville | Building | 1966 |
| Furnace Hills Tenant House | West Cocalico Township | Building | 2005 |
| Germania Turnverein Building | Lancaster | Building | 1980 |
| Good, John B., House | Bowmansville | Site | 1980 |
| Griest, W.W., Building | Lancaster | Building | 1999 |
| Grove Mansion | Maytown | Building | 1983 |
| Habeck, Christian, Farm | Lancaster | District | 1994 |
| Hager Building | Lancaster | Building | 1979 |
| Hamilton Apartments | Lancaster | Building | 1984 |
| Hammer Creek Bridge | Brunnerville | Structure | 1988 |
| Hand, Gen. Edward, House | Lancaster | Building | 1976 |
| Harnish, Johannes, Farmstead | West Lampeter Township | Building | 1999 |
| Harrisburg Avenue Tobacco Historic District | Lancaster | District | 1990 |
| Herr, Christian and Emma, Farm | Lancaster | District | 1994 |
| Herr, Hans, House | Lancaster | Building | 1971 |
| Herr's Mill Covered Bridge | Soundersbury | Structure | 1980 |
| Hess, A. B., Cigar Factory, and Warehouses | Lancaster | Building | 1982 |
| Hibshman Farm | Ephrata | Building | 1980 |
| Kagerise Store and House | Adamstown | Building | 1988 |
| Kaufman's Distillery Covered Bridge | Manheim | Structure | 1980 |
| Keller, Jacob, Farm | Ephrata | Building | 1986 |
| Keller's Covered Bridge | Ephrata | Structure | 1980 |
| Kirk Johnson Building | Lancaster | Building | 1983 |
| Kirks Mills Historic District | Nottingham | District | 1978 |
| Krauskap, Henry, House, and Store | Lancaster | Building | 1982 |
| Kreider Shoe Manufacturing Company | Elizabethtown | Building | 1980 |
| Lancaster Armory | Lancaster | Building | 1991 |
| Lancaster City Historic District | Lancaster | District | 2001 |
| Lancaster County Courthouse | Lancaster | Building | 1978 |
| Lancaster County House of Employment | Lancaster | Building | 1980 |
| Lancaster Crematorium | Lancaster | Building | 1983 |
| Lancaster Historic District | Lancaster | District | 1979 |
| Lancaster Historic District (Boundary Increase II) | Lancaster | District | 1984 |
| Lancaster Historic District (Boundary Increase) | Lancaster | District | 1983 |
| Lancaster Trust Company | Lancaster | Building | 1983 |
| Lancaster Watch Company | Lancaster | Building | 1982 |
| Landis Mill Covered Bridge | Lancaster | Structure | 1980 |
| Landis Valley Museum | Landis Valley | District | 2000 |
| Leaman Place Covered Bridge | Intercourse | Structure | 1980 |
| Lime Valley Covered Bridge | Refton | Structure | 1980 |
| Linden House | Marietta | Building | 1983 |
| Lititz Moravian Historic District | Lititz | District | 1986 |
| Locomotive No. 6755 | Strasburg | Structure | 1979 |
| Locust Grove | Bainbridge | Building | 1977 |
| Locust Grove Archaeological District | Bainbridge | District | 2020 |
| Manheim Borough Historic District | Manheim Borough | District | 2000 |
| Manor Street Elementary School | Columbia | Building | 1987 |
| Marietta Historic District | Marietta | District | 1978 |
| Marietta Historic District (Boundary Increase) | Marietta | District | 1984 |
| Martin, B. B., Tobacco Warehouse | Lancaster | Building | 1990 |
| Mascot Roller Mills | Mascot | Building | 1983 |
| Mascot Roller Mills (Boundary Increase) | Mascot | Building | 2013 |
| Mayer, David M., House | Lancaster | Building | 2017 |
| McGovern, Edward, Tobacco Warehouse | Lancaster | Building | 1990 |
| Mentzer Building | Ephrata | Building | 1985 |
| Mercer's Mill Covered Bridge | Christiana | Structure | 1980 |
| Mikado Freight Locomotive No. 520 | Strasburg | Structure | 1979 |
| Miller, David H., Tobacco Warehouse | Lancaster | Building | 1990 |
| Milleysack, J. B. Cigar Factory | Lancaster | Building | 1990 |
| Montgomery, William, House | Lancaster | Building | 2000 |
| Mount Hope Estate | Manheim | Building | 1980 |
| Mount Hope Estate (Boundary Increase) | Mount Hope | District | 1991 |
| Mountain Springs Hotel | Ephrata | Building | 1982 |
| Mumma, Samuel N., Tobacco Warehouse | Landisville | Building | 1997 |
| Murry Site | Washington | Site | 1980 |
| N. Shippen-Tobacco Avenue Historic District | Lancaster | District | 1990 |
| Neff's Mill Covered Bridge | Strasburg | Structure | 1980 |
| New Era Building | Lancaster | Building | 1983 |
| New Holland Machine Company | New Holland | Building | 2000 |
| Nissly Swiss Chocolate Company | Mount Joy | Building | 1996 |
| Nissly-Stauffer Tobacco Warehouses | Lancaster | Building | 1989 |
| North Charlotte Street Historic District | Lancaster | District | 1989 |
| North Prince Street Historic District | Lancaster | District | 1989 |
| Northeast Lancaster Township Historic District | Lancaster | District | 1986 |
| Old City Hall | Lancaster | Building | 1972 |
| Old Columbia-Wrightsville Bridge | Columbia | Structure | 1988 |
| Old Main, Goethean Hall, and Diagnothian Hall | Lancaster | Building | 1975 |
| Oregon Mill Complex | Oregon | Building | 1985 |
| Park Site 36La96 | Lancaster | Site | 1985 |
| Passenger and Baggage Car No. 4639 | Strasburg | Structure | 1979 |
| Passenger Coach No. 3556 | Strasburg | Structure | 1979 |
| Passenger Day Coach No. 8177 | Strasburg | Structure | 1979 |
| Passenger Locomotive No. 1223 | Strasburg | Structure | 1979 |
| Passenger Locomotive No. 1737 | Strasburg | Structure | 1979 |
| Passenger Locomotive No. 460 | Strasburg | Structure | 1979 |
| Passenger Locomotive No. 7002 | Strasburg | Structure | 1979 |
| Pine Grove Covered Bridge | Kirkwood | Structure | 1980 |
| Pinetown Covered Bridge | Lancaster | Structure | 1980 |
| Pool Forge Covered Bridge | Churchtown | Structure | 1980 |
| Poole Forge | Narvon | District | 1993 |
| Red Run Covered Bridge | Terre Hill | Structure | 1980 |
| Reilly Brothers and Raub Building | Lancaster | Building | 1983 |
| Reinholds Station Trinity Chapel | Reinholds | Building | 1990 |
| Reyer, Peter and Catherine, Farmhouse | Ephrata | Building | 1996 |
| Roberts Farm Site (36LA1) | Conestoga | Site | 1986 |
| Schnader, R. K. & Sons, Tobacco Warehouse | Lancaster | Building | 1990 |
| Schnader, Walter, Tobacco Warehouse | Lancaster | Building | 1990 |
| Seigrist's Mill Covered Bridge | Columbia | Structure | 1980 |
| Shearer's Covered Bridge | Manheim | Structure | 1980 |
| Shenk's Mill Covered Bridge | Manheim | Structure | 1980 |
| Shenks Ferry Site (36LA2) | Pequea | Site | 1982 |
| Sherman, L. G., Tobacco Warehouse | Lancaster | Building | 1990 |
| Shreiner Farm | Lancaster | District | 1994 |
| Shultz-Funk Site (36LA7 and 36LA9) | Washington Boro | Site | 1982 |
| Slater Cigar Company | Lancaster | Building | 1990 |
| Soldiers and Sailors Monument | Lancaster | Site | 1973 |
| Speedwell Forge Mansion | Elizabeth Township | Building | 2006 |
| Sprenger Brewery | Lancaster | Building | 1979 |
| Spring Grove Forge Mansion | East Earl | Building | 1984 |
| Stauffer, Christian, House | Lancaster | Building | 1986 |
| Steel Hopper Car No. 33164 | Strasburg | Structure | 1979 |
| Steel Passenger Coach No. 1650 | Strasburg | Structure | 1979 |
| Steel Passenger Coach No. 1651 | Strasburg | Structure | 1979 |
| Stehli Silk Mill | Lancaster | Building | 2014 |
| Steinman Hardware Store | Lancaster | Building | 1979 |
| Stevens High School | Lancaster | Building | 1983 |
| Stiegel-Coleman House NHL | Brickerville | Building | 1966 |
| Stoever, John Casper, Log House | New Holland | Building | 1987 |
| Strasburg Historic District | Strasburg | District | 1983 |
| Strickler Site | Washington | Site | 1973 |
| Sturgis, Julius, Pretzel House | Lititz | Building | 1974 |
| Sutter, Johann Agust, House | Lititz | Building | 1982 |
| Swarr, John and Elizabeth, House | Manheim Township | Building | 2020 |
| Switcher No. 1670 | Strasburg | Structure | 1979 |
| Switcher No. 94 | Strasburg | Structure | 1979 |
| Teller Brothers-Reed Tobacco Historic District | Lancaster | District | 1990 |
| Totten House | Lancaster | District | 1989 |
| U.S. Post Office | Lancaster | Building | 1981 |
| Wagner's, Charlie, Cafe | Lancaster | Building | 1983 |
| Walter, Henry, House | Blainsport | Building | 1984 |
| Weaver, Henry, Farmstead | Terre Hill | Building | 1978 |
| Weaver's Mill Covered Bridge | Churchtown | Structure | 1980 |
| Weber-Weaver Farm | West Lampeter | Building | 1999 |
| Werner, William, House | Lititz | Building | 1984 |
| West Lawn | Lancaster | Building | 1984 |
| White Chimneys | Gap | Building | 1975 |
| White Rock Forge Covered Bridge | Kirkwood | Structure | 1980 |
| Windom Mill Farm | Lancaster | District | 1994 |
| Windsor Forge Mansion | Churchtown | District | 1990 |
| Witmer's Tavern | Lancaster | Building | 1978 |
| Wooden Baggage Express No. 6 | Strasburg | Structure | 1979 |
| Wooden Express Baggage No. 6076 | Strasburg | Structure | 1979 |
| Wooden Hopper Gondola No. 1818 | Strasburg | Structure | 1979 |
| Woodward Hill Cemetery | Lancaster | District | 2005 |
| Wright's Ferry Mansion | Columbia | Building | 1979 |
| Yeates, Jasper, House | Lancaster | Building | 1982 |
| Zook's Mill Covered Bridge | Brownstown | Structure | 1980 |
Buchanan, James, House NHL Lancaster · Building · listed 1966 
Ephrata Cloister NHL Ephrata · District · listed 1967 
Fulton Opera House NHL Lancaster · Building · listed 1969 
Fulton, Robert, Birthplace NHL Quarryville · Building · listed 1966 
Stiegel-Coleman House NHL Brickerville · Building · listed 1966 
Abbeville Lancaster · Building · listed 1978 
American/Consolidated Tobacco Companies Lancaster · Building · listed 1990 
Andrews Bridge Historic District Colerain Twnshp · District · listed 1988 
Ashley and Bailey Silk Mill Marietta · Building · listed 1980 
B.F. Good & Company Leaf Tobacco Warehouse Lancaster · Building · listed 1985