| Allen, Henry, House | Moravia | Building | 1995 |
| Auburn Button Works and Logan Silk Mills | Auburn | Building | 2007 |
| Aurora Steam Grist Mill | Aurora | Building | 1976 |
| Aurora Village-Wells College Historic District | Aurora | District | 1980 |
| Belt-Gaskin House | Auburn | Building | 2005 |
| Burritt, Orrin W., House | Weedsport | Building | 2007 |
| Case Memorial-Seymour Library | Auburn | Building | 1980 |
| Cayuga County Courthouse and Clerk's Office | Auburn | Building | 1991 |
| Centreport Aqueduct | Weedsport | Structure | 2000 |
| Church Street-Congress Street Historic District | Moravia | District | 1994 |
| Cottage Farm | Fair Haven | Building | 2012 |
| Durkee, Almeron, House | Union Springs | Building | 2005 |
| Dwight, Charles Chauncy, House | Auburn | Building | 2015 |
| East Genoa Methodist Episcopal Church | Genoa | Building | 2002 |
| Erie Canal Lock 52 Complex | Port Byron | District | 1998 |
| First Baptist Church of Weedsport | Weedsport | Building | 2002 |
| First Presbyterian Church of Springport | Union Springs | Building | 2025 |
| Harriet Tubman Home for the Aged NHL | Auburn | Building | 1974 |
| Hosmer, William and Mary, House | Auburn | Building | 2006 |
| House at 15 East Cayuga Street | Moravia | Building | 1995 |
| House at 17 Aurora Street | Moravia | Building | 1995 |
| House at 18 Aurora Street | Moravia | Building | 1995 |
| House at 20 Aurora Street | Moravia | Building | 1995 |
| House at 21 West Cayuga Street | Moravia | Building | 1995 |
| House at 31 West Cayuga Street | Moravia | Building | 1995 |
| House at 36 South Main Street | Moravia | Building | 1995 |
| House at 37 West Cayuga Street | Moravia | Building | 1995 |
| House at 46 South Main Street | Moravia | Building | 1995 |
| Howland Cobblestone Store | Scipio | Building | 1994 |
| Howland, Augustus, House | Sherwood | Building | 2008 |
| Howland, Charles- William H. Chase House | Union Springs | Building | 2005 |
| Howland, Slocum and Hannah, House | Sherwood | Building | 2006 |
| Huntington, Ezra A., House | Auburn | Building | 2020 |
| Hutchinson Homestead | Cayuga | Building | 2009 |
| Ingham, William Smith, House | Meridian | Building | 2005 |
| Lakeside Park | Owasco | Site | 1989 |
| McGeer, John, House | Moravia | Building | 1995 |
| Mentz Church | Montezuma | Building | 2004 |
| Moravia Union Cemetery | Moravia | Site | 1995 |
| Morse Farm | Moravia | Building | 1995 |
| Mosher Farmstead | Aurora | District | 2003 |
| New Hope Mills Complex | New Hope | Building | 2005 |
| North Main Street Historic District | Moravia | District | 1993 |
| North Street Friends Meetinghouse | Ledyard | Building | 2005 |
| Otis, Job and Deborah, House | Sherwood | Building | 2008 |
| Owasco Reformed Church | Owasco | Building | 2010 |
| Peleg and Eunice White House | Ledyard | Building | 2025 |
| Richardson, William, House | Union Springs | Building | 2005 |
| Sager House | Moravia | Building | 1995 |
| Sand Beach Church | Auburn | Building | 1975 |
| Schine Auburn Theatre | Auburn | Building | 2000 |
| Seneca River Crossing Canals Historic District | Montezuma and Tyre | District | 2005 |
| Sennett Federated Church and Parsonage | Sennett | Building | 2005 |
| Seward, William H., House NHL | Auburn | Building | 1966 |
| Sherwood Equal Rights Historic District | Sherwood | District | 2008 |
| South Street Area Historic District | Auburn | District | 1991 |
| St. Peter's Episcopal Church Complex | Auburn | Building | 2002 |
| Sterling District No. 5 Schoolhouse | Sterling | Building | 2002 |
| Sterling Grist Mill Complex | Sterling | Building | 2002 |
| Thompson AME Zion Church | Auburn | Building | 1999 |
| Tryon, Frank and Eliza, House | Weedsport | Building | 2014 |
| Tubman Home for the Aged, Harriet Tubman Residence, Thompson A.M.E. Zion Church (Boundary Increase) NHL | Auburn | Building | 2001 |
| Tubman, Harriet, Grave | Auburn | Site | 1999 |
| Tubman, Harriet, House | Auburn | Building | 1999 |
| Tuthill-Green House | Moravia | Building | 1995 |
| US Post Office, Former, and Federal Courthouse | Auburn | Building | 1991 |
| Wall Street Methodist Episcopal Church | Auburn | Building | 1999 |
| West High School | Auburn | Building | 2017 |
| Willard Memorial Chapel-Welch Memorial Hall NHL | Auburn | Building | 1989 |
| Willard, Dr. Sylvester, Mansion | Auburn | Building | 1989 |
| Wood, Jethro, House NHL | Poplar Ridge | Building | 1966 |
| Yawger, Peter, House | Union Springs | Building | 2004 |
Harriet Tubman Home for the Aged NHL Auburn · Building · listed 1974 
Seward, William H., House NHL Auburn · Building · listed 1966 
Willard Memorial Chapel-Welch Memorial Hall NHL Auburn · Building · listed 1989 
Wood, Jethro, House NHL Poplar Ridge · Building · listed 1966 
Tubman Home for the Aged, Harriet Tubman Residence, Thompson A.M.E. Zion Church (Boundary Increase) NHL Auburn · Building · listed 2001 
Allen, Henry, House Moravia · Building · listed 1995 
Auburn Button Works and Logan Silk Mills Auburn · Building · listed 2007 
Aurora Steam Grist Mill Aurora · Building · listed 1976 
Aurora Village-Wells College Historic District Aurora · District · listed 1980 
Belt-Gaskin House Auburn · Building · listed 2005